Overview

Potentiation of Procedural Motor Learning in Health and Disease

Status:
Terminated

Trial end date:
2013-01-01

Target enrollment:
0

Participant gender:
All

Summary

The investigators plan to improve the learning of motor skills by pharmacological means (dopamine), and by noninvasive brain stimulation. They will study both healthy subjects and chronic stroke patients. In addition, they want to study the mechanisms of enhanced learning, on the molecular and the systems level.

Phase:

Phase 4

Accepts Healthy Volunteers?

Accepts Healthy Volunteers

Details

Lead Sponsor:

University Hospital Muenster

Treatments:

Dopamine
Dopamine Agents

Criteria

Inclusion Criteria:

Healthy Volunteers:

- Normal neurological examination

- Mini Mental State Examination of > 27

- Right handedness

Stroke Patients:

- Cortical or subcortical stroke with an initial severe hemiparesis Medical Research
Council (MRC) scale < 2 that has recovered to a degree that patients are able to
perform the proposed task (in general > MRC 4.5, with low spasticity, work in progress
on motor learning in stroke patients)

- At least 1 year post-stroke

- Mini Mental State Examination of > 27

- Right-handedness

Exclusion Criteria:

Healthy Volunteers and Stroke Patients:

- No antipsychotic, antidepressant drugs, and drugs affecting the dopaminergic system.