Potassium-titanyl Phosphate (KTP) Laser vs KTP Laser and Ivermectin Cream for Facial Rosacea
Status:
Active, not recruiting
Trial end date:
2024-09-30
Target enrollment:
Participant gender:
Summary
Rosacea is a frequent chronic inflammatory disease affecting mainly the face but also eyes
and scalp. Rosacea is classified into 3 types: erythemato-teleangiectatica, papulopustulosa
and phymatosa. Treatments depend on the type and include topical and systemic antibiotics,
azelaic acid, topical ivermectin, topical brimonidine, systemic isotretinoin as well as
intense pulsed light (IPL) and laser therapies.
For treatment of telangiectasia and redness, laser and IPL therapies are the first choice.
Vascular lasers, such as pulsed dye lasers (PDL) and potassium-titanyl phosphate (KTP) lasers
as well as IPL, have demonstrated good efficacy in reduction of erythema and telangiectasias
in patients with rosacea. However, these treatments are expensive and mostly not covered by
the health insurance. Therefore, for patients it is important to receive the maximal effect
and improvement after each single laser session.
Ivermectin is a semi-synthetic derivative of avermectin and has an anti-inflammatory effect
as well as an antiparasitic effect on demodex mite. The latter is playing an important
pathogenetic role in rosacea.
This randomized controlled study aims to compare the effect of KTP laser in combination with
ivermectin 1% cream vs KTP laser alone in patients with facial rosacea.