Potassium-Magnesium Citrate as a Blood Pressure Lowering Agent in Hypertensive Patients

• Status: Withdrawn
• Trial end date: 2012-12-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal of this study is to compare the effects of Potassium Magnesium Citrate to Potassium Chloride on blood pressure among patients with pre-hypertension or mild hypertension. We will also test whether Potassium Magnesium Citrate increases excretion of large amounts of sodium in the urine.

• Phase: Phase 1/Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: University of Texas Southwestern Medical Center
• Treatments: Citric Acid; Magnesium citrate

Criteria

Inclusion Criteria:

• Age greater than 21 years

• BMI > 18.5 kg/m2 and < 40 kg/m2

• Prehypertension and mild hypertension: BP systolic 120-159 mmHg, diastolic 80-95 mmHg

• Must agree to limit lifestyle changes including: 1) embarking on a new exercise or weight reduction program 2) altering alcohol intake during the trial.

Exclusion Criteria:

• Taking blood pressure lowering medication

• Diabetes mellitus

• Renal disease

• Active cardiac disease

• Active liver disease

• Chronic diarrhea

• Chronic NSAID use

• Active or suspected drug use

• Uncontrolled psychiatric disease

• HIV infection

• Missed more than 20% of clinic visits in the last yr

• Prescription of diuretics for any reason

• A patient taking nutritional supplements including multivitamins that is unwilling to discontinue them,\

• Consumption of greater than 14 alcoholic beverages per week