Overview
Postoperative Pain Control After Periarticular Injection During Total Knee Arthroplasty
Status:
Terminated
Terminated
Trial end date:
2021-02-11
2021-02-11
Target enrollment:
0
0
Participant gender:
All
All
Summary
This study will evaluate the use of a local injection around the knee (periarticular) during total knee replacement (TKR) surgery to see if it reduces postoperative pain levels. The injection is a combination of various medications which are thought to reduce pain levels. Approximately 128 patients will participate in this study, half of the patients will receive this injection during surgery and the other half will receive a saline (salt water) injection. Pain scores after the surgery will be compared between the two groups. All patients will also receive a long-acting (24 hours) morphine injection during surgery. The hypothesis is that those participants receiving intrathecal Duramorph and local periarticular injections will have improved pain scores and reduced narcotic use when compared with intrathecal Duramorph alone at 48 hours postoperatively.Phase:
Phase 4Accepts Healthy Volunteers?
Accepts Healthy VolunteersDetails
Lead Sponsor:
Virginia Commonwealth UniversityTreatments:
Clonidine
Epinephrine
Epinephryl borate
Ketorolac
Ketorolac Tromethamine
Racepinephrine
Ropivacaine
Criteria
Inclusion Criteria:- Age 18 or older
- Written informed consent
Exclusion Criteria:
- Pregnant women
- Creatinine clearance less than 60 ml/min
- BMI greater than 40
- Currently use greater than 80mg morphine-equivalents daily (pre-operatively)
- Receive a unicondylar knee replacement