Postoperative Delirium After Total Knee Arthroplasty Under Regional Anesthesia

• Status: Enrolling by invitation
• Trial end date: 2022-08-01
• Target enrollment: 0
• Participant gender: All

Summary

Postoperative delirium after total knee replacement surgery has been related to significant morbidity and mortality among high risk patients. Anesthetic care might play a role in the development of postoperative delirium.

The purpose of this study is to compare the incidence of postoperative delirium between different intraoperative sedation regimen. Delirium assessment using standardized screening tools will be done every 8 hours after surgery.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Mahidol University
• Treatments: Dexmedetomidine; Fentanyl; Propofol

Criteria

Inclusion Criteria:

• Age 65 year or older

• Scheduled for elective primary total knee arthroplasty

Exclusion Criteria:

• Contraindication for spinal anesthesia

• Contraindication for adductor canal block

• Allergy to fentanyl or propofol or dexmedetomidine or bupivacaine

• Cognitive impairment

• NSQIP database risk calculator > 10% overall complication

• Unable to communicate in Thai language

• Significant visual and hearing impairment