Overview

Postoperative Analgesic Effect of Esketamine

Status:
Completed
Trial end date:
2021-08-16
Target enrollment:
0
Participant gender:
Female
Summary
The aim of this study was to determine whether the addition of esketamine to morphine would improve postoperative analgesia after caesarean section. Parturients who planned for a caesarean delivery using combined spinal-epidural anaesthesia with a request for postoperative anaesthesia were randomly divided into four groups (A, B, C and D). When the surgery was completed, the parturients in groups A, B, C and D were administered 2 mg morphine, 0.25mg/kg of esketamine, 0.25mg/kg of esketamine plus 2 mg morphine sulfate and 0.25mg/kg of esketamine plus 1 mg morphine through the epidural catheters, respectively. The postoperative pain at rest, pain with movement, the number of rescue analgesics and adverse effects were evaluated for 48 h after caesarean delivery.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Xuanhan County People's Hospital
Treatments:
Esketamine
Morphine
Criteria
Inclusion Criteria:

- nulliparous parturients who scheduled for elective caesarean delivery under
spinal-epidural anaesthesia;

- parturients who had requested postoperative analgesia;

- parturients aged between 20-35 years old;

- parturients who had a full-term pregnancy;

- parturients who were identified as having a singleton pregnancy; and

- parturients who were categorised as having an American Society of Anaesthesiologists
(ASA) physical status

Exclusion Criteria:

- parturients with severe internal, surgical or obstetric comorbidities (including
spinal deformities, hypertension, placental abruption, cholestasis in pregnancy,
asthma, heart disease and abnormal coagulation parameters)

- parturients with a known allergy to the drugs used in this study

- parturients with severe mental illness who could not comply with doctors' instructions

- parturients with chronic pain syndrome, which is defined as pain that persists for a
period longer than 3 months