Postmenopausal Facial Skin After Estradiol and Genistein Topical Treatment
Status:
Completed
Trial end date:
2005-03-01
Target enrollment:
Participant gender:
Summary
The aim of this trial was to compare the effects of estradiol or genistein treatment on the
hialuronic acid concentration on the postmenopausal facial skin. In this study, 30
postmenopausal women were evaluated through a prospective, randomized, double-blind trial.
The volunteers were postmenopausal women treated in the Gynecology Department of the Federal
University of São Paulo (UNIFESP). The participants were divided into two groups: group E,
treated with 17 β estradiol gel 0.01% (n = 15), and group G, treated with genistein gel 4 %
(isoflavones, n=15). The length of treatment was 24 consecutive weeks. Preauricular skin
biopsies were performed on each patient before and after the treatment for evaluating
hyaluronic acid in the tissue. The materials were processed through immunohistochemical and
biochemical methods.
Phase:
Phase 2
Details
Lead Sponsor:
Federal University of São Paulo
Collaborator:
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior.