Following surgical procedures or injury, cutaneous scars can develop due to production of
collagen-rich connective tissue. These scars may be accompanied by redness, itching, pain,
and restricted mobility of the skin. Typically, after a few weeks, the scar matures, becoming
lighter and narrower, although full maturation of a scar may take up to 2 years. In some
cases, however, cutaneous scars can be unsightly or can even become hyper- trophic or result
in keloids.
Preventing pathological scarring is much easier than treating scars later and should be
started as early as possible after the injury or surgery.
CACIPLIQ20® is a medical device used for the treatment of chronic skin ulcers, and contains a
molecule belonging to the family of ReGeneraTing Agents (RGTA®). RGTA®s are biodegradable
polymers that mimic the action of heparan sulfates found in the extracellular matrix of
injured tissues. RGTA® accelerates tissue healing in various animal models, by stabilizing
and protecting heparin-binding growth factors (HBGFs) and matrix proteins. In addition to its
effects on hard-to-heal chronic wounds, CACIPLIQ20® was found to improve acute wound healing
in pre-clinical models and in several case reports and controlled clinical studies. A first
open label-controlled study showed that the topical application of RGTA® improved skin
healing in mammoplasty patients and notably reduced oedema and pain in patients who had
undergone centrofacial lift surgery compared to untreated patients. Results from this first
study were confirmed in a double-blind placebo self-controlled trial conducted in two medical
institutions in China involving 71 patients. The Chinese study showed that a single
application of CACIPLIQ20® significantly improved scar healing quality at 14 days as well as
scar symptoms including pain, swelling and exudate. The aim of the MATRISCAR study is to
confirm the previous results in a double-blind, placebo-controlled randomized clinical trial.
Phase:
Phase 3
Details
Lead Sponsor:
Organ, Tissue, Regeneration, Repair and Replacement