Overview

Post-resection/Ablation Chemotherapy in Patients With Metastatic Colorectal Cancer (FIRE-9 - PORT / AIO-KRK-0418)

Status:
Not yet recruiting

Trial end date:
2030-10-01

Target enrollment:

Participant gender:

Summary

This is an open-label, randomized, controlled, multicenter, phase III study with two parallel arms. Patients with metastatic colorectal cancer after definite interventional therapy of all lesions are randomized in a 2:1 fashion (favoring active therapy) to investigate the efficacy, patient reported quality of life and safety of mFOLFOXIRI/mFOLFOX-6 as additive treatment (Arm A) versus active follow-up/surveillance (Arm B).

Phase:

Phase 3

Details

Lead Sponsor:

Dominik Paul Modest

Collaborators:

German Research Foundation
Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest

Treatments:

Fluorouracil
Irinotecan
Leucovorin
Levoleucovorin
Oxaliplatin