Overview

Post-preeclampsia Renal Project: Study of Nephroprotection in Women Having Suffered Preeclampsia

Status:
Completed
Trial end date:
2018-03-01
Target enrollment:
0
Participant gender:
Female
Summary
The purpose of the Post-preeclampsia Renal Project is to investigate the renal function of preeclamptic women after delivery, and to determine whether the anti-hypertensive drug named benazepril efficiently improves the dysfunctions observed.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
University Hospital, Geneva
Treatments:
Benazepril
Criteria
Pre-selection Criteria:

- Normotensive women with no proteinuria before the 20th week of gestation AND

- Women with hypertension (BP ≥140/90 mm Hg) and proteinuria (≥ 0.3 g /24h or 2++
dipstick) after the 20th week of gestation

Inclusion Criteria:

- Clearance of creatinine ≤ 80 ml/min (Gault et Cockcroft)

- Serum creatinine ≥ 80 µmol/L

- Microalbuminuria comprised between 30 and 300 mg/d and/or a urinary spot with
microalbuminuria/creatinine ratio ≥ 3.5 and/or macroalbuminuria (24h urinary albumin
excretion ≥ 0.500 mg)

- BP ≥ 140/90 mm Hg OR ongoing antihypertensive treatment

- CRP ≥ 4 mg/dL

Exclusion Criteria:

- Those unlikely to co-operate in the study

- Those who refuse to use appropriate contraceptive measures during the treatment period
(intrauterine device, oral contraceptives, condom, diaphragm)

- Those with a history of pre-term delivery

- Those with known history of severe allergic reaction

- Those who consume drugs

- Aged < 18 years old