Post-operative Methylprednisolone Taper Course for Orthopedic Surgery
Status:
Enrolling by invitation
Trial end date:
2023-04-01
Target enrollment:
Participant gender:
Summary
The clinical trial is a prospective randomized control trial of a group of patients
undergoing surgical management of common orthopedic pathologies including fractures of the
upper extremity and shoulder arthroplasty; patients undergoing total hip arthroplasty for
osteoarthritis of the hip or total knee arthroplasty for osteoarthritis of the knee.
Patients will be assigned randomly to one of two treatment arms: (1) single intraoperative
dose of 10 mg intravenous dexamethasone (control group, IV dexamethasone is standard of care)
or (2) single intraoperative dose of 10 mg intravenous dexamethasone followed with a 6-day
oral methylprednisolone taper course (Active Group).
The purpose of this study is to study the efficacy of a post-operative course of
glucocorticoids (GCs like Methylprednisolone) on pain, nausea and range of motion after
surgical management of common orthopedic upper extremity pathologies, including fractures of
the upper extremity and shoulder arthroplasty and patients undergoing total hip arthroplasty
for osteoarthritis of the hip or total knee arthroplasty for osteoarthritis of the knee.