Post-operative Adjuvant Treatment for HPV-positive Tumours (PATHOS)
Status:
Recruiting
Trial end date:
2027-04-01
Target enrollment:
Participant gender:
Summary
The main objectives of the PATHOS study are:
To assess whether swallowing function can be improved following transoral resection of
HPV-positive OPSCC, by reducing the intensity of adjuvant treatment protocols. The aim is to
personalise treatment, based on disease biology (HPV status and pathology findings), to
optimise patient outcomes.
To demonstrate the non-inferiority of reducing the intensity of adjuvant treatment protocols
in terms of overall survival in the reduced intensity treatment arms.
Phase:
Phase 3
Details
Lead Sponsor:
Lisette Nixon
Collaborators:
AdventHealth European Organisation for Research and Treatment of Cancer - EORTC Princess Alexandra Hospital, Brisbane, Australia UNICANCER University of Leipzig