Overview

Post-op Ketamine Study

Status:
Unknown status
Trial end date:
2019-04-27
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this study is to establish the effect of sub-anesthetic dosing of ketamine with spinal anesthesia during total knee arthroplasty on post-operative pain and narcotic consumption. We hypothesize that sub-anesthetic ketamine will decrease post-operative pain and narcotic consumption and may secondarily lead to shorter lengths of stay, faster rehabilitation, improved postoperative outcomes and patient satisfaction.
Phase:
N/A
Details
Lead Sponsor:
Rothman Institute Orthopaedics
Treatments:
Ketamine
Criteria
Inclusion Criteria:

- 18 - 85 years of age

- ASA I - IV

- Undergoing primary unilateral elective total knee arthroplasty with spinal anesthesia

Exclusion Criteria:

- BMI over 40*

- Contraindication or allergy to opioid pain medication or ketamine*

- Daily opioid use for pain control before surgery in excess of systemic morphine
equivalent to 10 mg*

- Ejection fraction (EF) less than 30%

- Creatinine clearance less than 30 mL/min*

- History of chronic liver failure

- Desire for nerve block or general anesthesia

- Any neurologic or psychiatric disorder (including bipolar disorder, post traumatic
stress disorder, schizophrenia)

- Prior surgery on ipsilateral knee within the last 6 months

- Alcohol abuse