Post-op Acetaminophen vs NSAID Use on Lumbar Spinal Fusion Outcomes
Status:
Active, not recruiting
Trial end date:
2023-03-01
Target enrollment:
Participant gender:
Summary
Patients undergoing spine surgery often have considerable pain post-operatively and
frequently require opioid medication (Percocet, Norco, oxycodone, morphine, etc.) to control
their pain postoperatively. The widespread use of opioids, however, is associated with a
number of side effects. These include: sedation, dizziness, nausea, vomiting, constipation,
dizziness and itching amongst others. Some investigators have suggested that
anti-inflammatory medications (the same class of medicines as advil, ibuprofen, etc.) and
acetaminophen (Tylenol) can reduce the total dose of opioid required postoperatively and, as
a result, lower opioid-related side effects.
The purpose of this study is to test this hypothesis and determine if postoperative
anti-inflammatory medications and postoperative acetaminophen can reduce the amount of opioid
required to control pain following surgery. A secondary goal of this study is to examine if
the change in pain medication will lead to decreased overall pain levels, decreased
opioid-related side effects and improved function [quicker ambulation with physical therapy
(PT), earlier return to work, etc.].