Post-Surgical Injection With Triamcinolone Versus Triamcinolone/Fluorouracil in Treatment of Keloids
Status:
Recruiting
Trial end date:
2023-12-31
Target enrollment:
Participant gender:
Summary
There have been many modalities utilized in the treatment of keloids of the head and neck,
however none have been universally successful. The most widely utilized non-surgical
intervention is primary intralesional injection with triamcinolone (TAC) which inhibits the
proliferation of fibroblasts, inhibits collagen synthesis, and increases collagenase
production, or fluorouracil (5-FU), a potent inhibitor of fibroblast proliferation. Despite
the abundance of studies evaluating primary intralesional injection for keloids, there are
limited studies available regarding the efficacy of primary surgical excision followed by
adjuvant intralesional injection. The proposed study herein would serve to improve the level
of evidence and to establish the safety and efficacy of combined intralesional TAC+5FU for
keloids following surgical excision.
Phase:
N/A
Details
Lead Sponsor:
Our Lady of the Lake Hospital
Collaborator:
Louisiana State University Health Sciences Center in New Orleans