Post-Operative Urinary Retention (POUR) in Thoracic Surgery Patients Receiving Prophylactic Tamsulosin

• Status: Not yet recruiting
• Trial end date: 2023-12-31
• Target enrollment: 0
• Participant gender: Male

Summary

Post-Operative Urinary Retention (POUR) in Thoracic Surgery is a prospective interventional study aiming to test the hypothesis that the prophylactic use of tamsulosin prior to thoracic surgery in high risk patients leads to reduce the rates of POUR.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Feiran Lou
• Collaborator: UMass Memorial Health Care
• Treatments: Tamsulosin

Criteria

Inclusion Criteria:

• All male patients >=60 years old who undergo inpatient thoracic surgery for major resections.

Exclusion Criteria:

• - Prisoners

• Adults unable to consent

• End stage renal disease on hemodialysis

• Indwelling urinary catheter

• Child-Pugh class C hepatic failure

• Usage of the following medications prior to surgery: strong CYP 3A4 inhibitors, strong CYP2D6 inhibitors, other alpha-adrenergic blocking agents, PDE5 inhibitors, and cimetidine

• patients known to be CYP2D6 poor metabolizers

• History of prostatectomy or cystectomy

• Patients with contraindications to tamsulosin and those at high risk for side effects:

hypersensitivity to tamsulosin HCl or any component of FLOMAX capsules, hypersensitivity to sulfonamides. History of known glaucoma, hypotension, plan to undergo cataract surgery in the next 2 weeks