Post-Operative Nausea and Vomiting in Children Submitted to Strabismus Surgery
Status:
Unknown status
Trial end date:
2020-07-01
Target enrollment:
Participant gender:
Summary
Background: Postoperative nausea and vomiting (PONV) is one of the main causes of patient and
family dissatisfaction, which may delay the onset of oral intake and postpone discharge. In
pediatric patients, the incidence of PONV is high, and in some studies it can reach values of
70%. Strabismus surgery is considered an independent risk factor for PONV. Palonosetron is a
second generation antiemetic drug, 5-hydroxytryptamine receptor antagonist, with a long
half-life, which allows single dose administration and has been shown to be safe and
effective in the treatment of chemotherapy induced nausea and vomiting, and has been used
with satisfactory results in the prophylaxis of PONV in adult and pediatric patients. Studies
involving palonosetron are still scarce.