Post-Operative Dosing of Dexamethasone in Patients With Brain Tumors After a Craniotomy, PODS Trial
Status:
Not yet recruiting
Trial end date:
2028-07-30
Target enrollment:
Participant gender:
Summary
This phase II trial tests the effect of decreasing (tapering) doses of dexamethasone on
steroid side effects in patients after surgery to remove (craniotomy) a brain tumor. Steroids
are the gold standard post-surgery treatment to reduce swelling (edema) at the surgical site
to reduce neurological symptoms. Although, corticosteroids reduce edema, they have side
effects including high blood sugar, high blood pressure, and can impair wound healing.
Dexamethasone is in a class of medications called corticosteroids. It is used to reduce
inflammation and lower the body's immune response. It also works to treat other conditions by
reducing swelling and redness. Tapering doses dexamethasone may decrease steroid side effects
without increasing the risk of edema in patients with brain tumors after a craniotomy.