Post Operative Adjuvant Therapy De-intensification Trial for Human Papillomavirus-related, p16+ Oropharynx Cancer
Status:
Terminated
Trial end date:
2019-10-18
Target enrollment:
Participant gender:
Summary
This clinical trial studies the intensity of adjuvant ("helper") therapy required in p16
positive oropharynx cancer patients, who have had all known disease removed surgically by a
minimally invasive approach, and who have extracapsular spread in their lymph nodes. Patients
can consent to participate in either the randomized (physician chooses radiotherapy arm or
radiotherapy & cisplatin arm) or non-randomized (patient chooses radiotherapy arm or
radiotherapy & cisplatin arm) pathways. After the surgery, receive either radiation alone, or
radiation and weekly cis-platinum during therapy. Patients are then followed for cancer,
functional and quality of life outcomes.