Restoring the patency of the coronary vessels and providing the ischemic myocardium with
reperfused blood can cause additional tissue damage. A key element of ischemia and
reperfusion (I/R) injury and major determinant of the evolution of damage in the affected
myocardium is the inflammatory response. The main objective of the study is to evaluate the
efficacy of colchicine in reducing I/R injury by effectively modulating the inflammatory
response in the reperfused myocardium.