Positron Emission Tomography (PET) Study to Describe the Relationship Between Plasma Concentrations and Brain Gly-T1 Occupancy of GSK1018921 Over Time.

• Status: Completed
• Trial end date: 2008-12-22
• Target enrollment: 0
• Participant gender: Male

Summary

A PET study using [11c]GSK931145 to characterise the exposure-occupancy relationship over time for GSK1018921.

• Phase: Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: GlaxoSmithKline
• Treatments: Glycine

Criteria

• Inclusion criteria:

• Healthy male subjects

• Age: 18-55 years

• No history of physical, neurological or mental illness

• Exclusion criteria

• History of claustrophobia or inability to lie still in the PET camera for at least 2 hours

• Cardiac pacemakers or metal implants in the body that contraindicate MRI scan.

• History of regular alcohol consumption (weekly intake >21 units) within the previous six months.