Overview

Posaconazole Treatment of Invasive Fungal Infection (IFI) (P05551)

Status:
Completed
Trial end date:
2010-03-01
Target enrollment:
0
Participant gender:
All
Summary
The purpose of this multicenter, open label study, is to evaluate the safety and efficacy of a 12-week treatment with Posaconazole Oral Suspension in participants with IFI
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Merck Sharp & Dohme Corp.
Treatments:
Posaconazole
Criteria
Inclusion Criteria:

- Participants must be 18-70 years male or female

- Identified or clinically diagnosed IFI participants or high risk population who are
resistant to, or recurrent from, or intolerable to, or may suffer toxic reaction from
standard antifungal treatment.

- Sign informed consent form

Exclusion Criteria:

- Female participants who are pregnant or are nursing.

- Participants with known or suspected hypersensitivity or idiosyncratic reaction to
azole agents or amphotericin B

- Participants with progressive nervous system diseases( excluding those IFI caused)

- Participants who take the following drugs known with interference with azole
antifungal preparations

- terfenadine, cisapride, and ebastine within 24 hours before entry

- astemizole at entry or within 10 days before entry

- cimetidine, rifampin, carbamazepine, phenytoin, rifabutin, barbiturates,
isoniazid atharanthine and anthracyclines within 24 hours before entry

- The drugs listed above are prohibited during the investigation

- Serious organ diseases except hematological disorder such as cardiac or neurologic
disorders or impairment expected to be unstable or progressive during the course of
this study (eg, seizures or demyelinating syndromes, acute myocardial infarction
within 3 months of study entry, myocardial ischemia, congestive heart failure, atrial
fibrillation with ventricular rate <60/min, or history of torsades de pointes,
symptomatic ventricular or sustained arrhythmias), unstable electrolyte abnormalities.

- Participants having an ECG with a prolonged QTc interval: QTc greater than 450 msec
for men and greater than 470 msec for women.

- Expected to take during investigation or is taking systemic antifungal treatment

- Participants with severe renal insufficiency (estimated creatinine clearance less than
50 mL/minute or likely to require dialysis during the study), ALT,AST AKP or total
bilirubin are >2×ULN.

- Participants expected to survive no more than 72hrs

- Participants receiving artificial aeration and will not withdraw within 24hrs

- Participants who have used any investigational drugs or biologic agents or anticipated
other clinical trials within 30 days of study entry.

- Prior enrollment in this study.

- History of alcohol and/or drug abuse.

- Participants cannot be compliant in investigator's opinion.