Population Pharmacokinetics of Dexmedetomidine in ICU Patients

• Status: Completed
• Trial end date: 2010-12-01
• Target enrollment: 0
• Participant gender: All

Summary

Dexmedetomidine is a new, highly selective and potent alpha2-adrenoreceptor agonist registered for sedation of patients in intensive care units. Although the pharmacokinetics of dexmedetomidine have been studied previously also in an ICU setting, there is no information on the pharmacokinetics of long-lasting (>48 hours) dexmedetomidine infusions in humans.

The aim of this study is to study the pharmacokinetics of long-lasting dexmedetomidine infusions in ICU patients using the population pharmacokinetics approach.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Turku
• Treatments: Dexmedetomidine

Criteria

Inclusion Criteria:

• Age ≥ 18 years.

• Need for dexmedetomidine sedation (determined by the responsible physician).

• Predicted length of dexmedetomidine sedation ≥ 48 hours.

• Written informed consent from the patient or the relatives of the participating patient.

Exclusion Criteria:

• A previous history of intolerance to the study drug or related compounds and additives.

• Existing significant haematological, endocrine, metabolic or gastrointestinal disease