Population Pharmacokinetics and Pharmacogenomics of Oral Oxycodone in Pediatric Surgical Patients
Status:
Recruiting
Trial end date:
2022-12-01
Target enrollment:
Participant gender:
Summary
Oxycodone is an oral opioid analgesic that is most commonly prescribed for the management of
pain in post-operative patients at Boston Children's Hospital. Oxycodone has been widely used
in adults and children to relieve post-operative pain. However, its pharmacokinetics (what it
does in the body) and pharmacodynamics (how it works) have not been well established in
children. Some children, because of their specific genetic make-up, may metabolize the drug
more quickly and therefore may be at risk for more side effects in the commonly prescribed
dose. We would like to find out more about how this drug is absorbed, metabolized and
excreted in children. In order to study these aspects, we would like to give oxycodone to
surgical patients at Boston Children's Hospital then measure its metabolic activity and also
perform a genetic analysis. The genetic testing is specifically to analyze the following
genotypes only: cytochrome P450 2D6 (CYP2D6) and cytochrome P450 3A4 (CYP3A4), which
represent the differences in cytochrome P450 metabolism of oxycodone.
Phase:
Phase 4
Details
Lead Sponsor:
Boston Children's Hospital Boston Children’s Hospital