Polypill Effects on Sub Clinical Atherosclerosis (PESCA) Trial
Status:
Completed
Trial end date:
2012-09-01
Target enrollment:
Participant gender:
Summary
Medications that lower blood pressure and cholesterol are known to improve the shape and
function of our blood vessels. These improvements include a reduction in the thickness of the
wall of the carotid artery (the main artery that runs up the neck to supply the brain) and a
reduction in the stiffness of arteries generally including the main central artery -the
aorta. Such medications are in the polypill (the Red Heart Pill) that is being used in the
UMPIRE Study. In UMPIRE, patients' reported adherence to taking the single, once daily
polypill is being compared to adherence to medications taken as separate tablets (usual
care).The aim of the PESCA sub-study is to see whether or not the polypill differs from
'usual care' in its direct effects on blood vessels as shown by ultrasound examination of the
carotid arteries and assessment of central (aortic) blood pressure.
Phase:
Phase 3
Details
Lead Sponsor:
Imperial College London
Collaborators:
Imperial College Healthcare NHS Trust Royal College of Surgeons, Ireland UMC Utrecht