Polycystic Ovary Syndrome Genetics and Treatment Response
Status:
Unknown status
Trial end date:
2019-10-01
Target enrollment:
Participant gender:
Summary
Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in reproductive age
women. Women with PCOS have a high risk of prediabetes, type 2 diabetes and heart disease.
The investigators have found a possible change in the DNA (genes of the body that encode all
of our traits) that seems to be related to insulin resistance. In this study, the
investigators will try to determine whether the change in the gene affects a woman's ability
to respond to a common treatment for PCOS, metformin.
These studies will uncover the change in a gene that might be one of the causes of PCOS.
Discovering this gene will help better understand the diabetes and insulin abnormalities that
are common in PCOS and will help us to better diagnose and treat PCOS to prevent the diabetes
in these women.