Polyamine-free Diet to Prevent Post Surgery Hyperalgesia
Status:
Completed
Trial end date:
2009-05-01
Target enrollment:
Participant gender:
Summary
After surgery, sensitization and hyperexcitability of central nervous system result in acute
and long lasting postoperative pain. It has been shown that N-methyl-D-aspartate (NMDA)
receptors antagonist (such as ketamine) prevent this adverse neuroplasticity and potentiate
analgesic drugs efficacy. Polyamines (putrescine, spermidine, spermine) are essential
components of cells functioning and are also known as allosteric modulators of NMDA
receptors. In animal studies, polyamine-free diet has confirmed these antinociceptive
properties. This research aims at evaluating anti hyperalgesic properties of polyamine-free
diet in women operated on breast cancer versus kétamine
Phase:
Phase 2
Details
Lead Sponsor:
University Hospital, Bordeaux
Collaborators:
Insurance CNP foundation Ministry of Health, France