Pleiotropic Effects of Atorvastatin in High Cardiovascular Risk Patients

• Status: Completed
• Trial end date: 2012-02-01
• Target enrollment: 0
• Participant gender: All

Summary

The present study constitutes a study examining the effect of atorvastatin on vascular function in high cardiovascular risk patients. For this purpose the investigators will record atorvastatin effects on statin-naïve patients (patients that start statins treatment for first time). More specifically the investigators will study atorvastatin effects on:

1. Endothelial function

2. Arterial elastic properties

3. Systemic Inflammatory/thrombotic mechanisms

4. Vascular and myocardial redox state

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Hippocration General Hospital
• Treatments: Atorvastatin; Atorvastatin Calcium

Criteria

Inclusion Criteria:

• Patients with coronary artery disease confirmed by coronary angiography.

• Patients undergoing cardiac surgery such as elective coronary bypass artery grafting (CABG), valve replacement or aortic surgery.

• All patients will not be under statins treatment for at least 6 months before their inclusion to the study.

Exclusion Criteria:

• Acute coronary syndrome during the last 2 months

• Renal failure (creatinine > 2,2 mg/dl)

• Severe liver disease. Prospective follow-up of liver enzymes will be performed by the physicians in charge, as indicated by the relative guidelines regarding statins use and according to the current clinical practice.

• Any chronic/acute inflammatory disease, autoimmune disease and/or cancer

• Use of anti-inflammatory drugs or vitamins supplements