Platelet-rich Plasma and Synovial Cytokines in Knee Osteoarthritis
Status:
Completed
Trial end date:
2020-03-14
Target enrollment:
Participant gender:
Summary
A prospective study was performed on 90 patients were included and categorized into mild (30
cases, moderate (30 cases) and severe (30 cases) knee OA. Three intra-articular (I.A)
injections of PRP, 2 weeks a part, were received. Pain score and MRI Osteoarthritis Knee
Score (MOAKS) were assessed. Serial synovial fluid cytokines assays in the form of Tumor
necrosis factor-α (TNF-α) and Macrophage migration inhibitory factor (MIF), were performed
using commercially available ELISA assay kits. The assays were performed pre-injection (S1),
two weeks from the 1st I.A injection and two weeks from the 2nd I.A injection (S3) for all
included patients.