The most common cause of acute upper gastrointestinal bleeding (UGIB) is non-variceal, where
peptic ulcer bleeding (PUB) remains the single most common cause, accounting for 25% to 67%
of the causes of non-variceal upper gastrointestinal bleeding (NVUGIB).
Despite major advances in diagnostic and therapeutic tools, PUB remains a significant problem
and an important cause of morbidity and mortality. Given the imperative therapeutic role of
endoscopic management in achieving hemostasis in NVUGIB, new modalities to improve the
current treatment strategies continue to be developed.
Platelet-rich plasma (PRP) is a widely used throughout many fields of medicine for improving
tissue regeneration. PRP contains a higher concentration of platelets than whole blood, and
represents a pool of many growth-factors.