Platelet Rich Fibrin With 1% Metformin Gel for Treatment of Intrabony Defects
Status:
Completed
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
ABSTRACT:
Background: Platelet-rich fibrin (PRF) is a second-generation platelet concentrate which
releases various growth factors that promote tissue regeneration. Metformin (MF), a member of
biguanide group has been shown to facilitate osteoblast differentiation and thus may exhibit
a favourable effect on alveolar bone . Current study was designed to evaluate the combined
efficacy of PRF and 1% MF gel with open flap debridement (OFD) in treatment of intrabony
defects in chronic periodontitis (CP) subjects.
Methods: One hundred and twenty subjects with single defects were categorized into four
treatment groups: OFD alone, OFD with PRF, OFD with 1% MF and OFD + PRF+1% MF. Clinical
parameters like site specific plaque index (PI), modified sulcus bleeding index (mSBI),
probing depth (PD), relative attachment level (RAL) and gingival marginal level (GML) were
recorded at baseline before surgery and 9 months post-operatively. Percentage radiographic
intra-bony defect depth reduction was evaluated using computer-aided software at baseline and
9 months.
Phase:
Phase 2
Details
Lead Sponsor:
Government Dental College and Research Institute, Bangalore