Platelet Reactivity With Fentanyl, Morphine, or no Narcotic

• Status: Not yet recruiting
• Trial end date: 2023-06-01
• Target enrollment: 0
• Participant gender: All

Summary

The goal is to determine whether fentanyl and morphine have similar effects in reducing aspirin's effect upon platelets in emergency department patients with chest discomfort. Morphine has been shown to worsen outcomes in heart attack patients due to reduction of oral anti-platelet agent effectiveness and so many providers have switches to using fentanyl. However, it is largely unknown whether fentanyl has similar effects.

• Phase: Early Phase 1
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Spectrum Health - Lakeland
• Treatments: Fentanyl; Morphine

Criteria

Inclusion Criteria:

• Adult Emergency Department patients undergoing 0 and 2 hour troponin testing

• administered aspirin within 30 minutes of the initial blood draw.

• patient presented via private vehicle

• provide informed consent

Exclusion Criteria:

• Patients not expected to get a 2 hour troponin;

• patients already on aspirin, clopidogrel, or stronger anti-coagulants;

• patients who arrived via EMS (Emergency Medical Services) given it can be difficult to find the run reports to determine whether patient received fentanyl in the pre-hospital period;

• pregnant patients;

• patients on chronic narcotics;

• patients already once enrolled in this study,

• inability to provide consent in English