Platelet Inhibition by Aspirin, Acetaminophen and NSAID
Status:
Completed
Trial end date:
2007-08-01
Target enrollment:
Participant gender:
Summary
Nonsteroidal antiinflammatory drugs such as diclofenac or naproxen may interfere with the
inhibition of platelet aggregation by aspirin, because they all interact with the platelet
cyclooxygenase.This may be of great clinical importance because of an increased
cardiovascular event rate (myocardial infarction, stroke). The present randomized, controlled
study analyses in vitro platelet aggregation under a combined treatment of healthy volunteers
with aspirin and either acetaminophen, diclofenac, naproxen, or placebo.