Overview

Platelet Inhibition by Aspirin, Acetaminophen and NSAID

Status:
Completed
Trial end date:
2007-08-01
Target enrollment:
0
Participant gender:
All
Summary
Nonsteroidal antiinflammatory drugs such as diclofenac or naproxen may interfere with the inhibition of platelet aggregation by aspirin, because they all interact with the platelet cyclooxygenase.This may be of great clinical importance because of an increased cardiovascular event rate (myocardial infarction, stroke). The present randomized, controlled study analyses in vitro platelet aggregation under a combined treatment of healthy volunteers with aspirin and either acetaminophen, diclofenac, naproxen, or placebo.
Phase:
N/A
Accepts Healthy Volunteers?
Accepts Healthy Volunteers
Details
Lead Sponsor:
Kantonsspital Graubünden
Treatments:
Acetaminophen
Aspirin
Diclofenac
Naproxen
Criteria
Inclusion Criteria:

- Healthy volunteers

Exclusion Criteria:

- Administration of drugs affecting platelets

- History of bleeding

- Gastrointestinal disorders

- Hypersensitivity to aspirin and/or NSAID

- Pregnancy and breast feeding