Fluid resuscitation remains the cornerstone for the care of severe trauma patients to
compensate for blood loss, to compensate for capillary leak induced by systemic inflammation
but also to prevent the detrimental consequences of traumatic rhabdomyolysis. Isotonic saline
(NaCl 0.9%), called "physiological serum" is the standard fluid for the resuscitation of
severely injured patients. However, the formulation of NaCl 0.9% is not really physiological
since its chloride concentration is 1.5 higher than the one of human plasma. This excessive
chloride concentration leads to hyperchloremic acidosis and to a drop in renal perfusion
after isotonic saline infusion. For this reason, we wonder whether fluid resuscitation with
Plasmalyte would be beneficial for renal function of trauma patients in comparison with NaCl
0.9%. Our research question is:
In a population of trauma patients at high risk of acute kidney injury, does a fluid
resuscitation with Plasmalyte Viaflo lower the incidence of severe acute kidney injury (stage
2 or 3 according to the KDIGO classification) compared with a resuscitation with isotonic
saline (NaCl 0.9%)?