The treatment of patients with major burns requires resuscitation with massive amounts of
fluid, typically a type of salt water that is given by vein. This frequently results in
injury to vital organs, especially the lungs and kidneys, and even in death. In this study,
the investigators propose to use plasma, a specially prepared blood product made from the
liquid part of blood, that has undergone special treatment to reduce the risk of disease
transmission. The aims include 1) reduce the amount of fluid given during the first 24 hours
after a burn 2) reduce the incidence of lung injury and other complications related to the
administration of funds and 3) determine if the blood product has any effect on inflammation.
An overall decrease the amount of fluids that burn patients receive should decrease the
potential for lung injury, decrease days in the hospital, and improve survival.