Plasma Gabapentin Concentration During and Following Cardiac Bypass
Status:
Completed
Trial end date:
2007-09-01
Target enrollment:
Participant gender:
Summary
This open label investigation is to determine whether cardiopulmonary bypass affects plasma
gabapentin concentration after preoperative administration in the setting of cardiac bypass
surgery. Following signed informed consent, 16 patients scheduled for cardiac bypass surgery
will be given gabapentin (600mg, oral) 1 hour prior to surgery, 1 hour following extubation
and then every 8 hours for a total of 4 doses. Plasma gabapentin levels will be measured
prior to induction, prior to bypass, 10 min into the bypass procedure, 10 minutes before
separation from bypass, 30 minutes following bypass and then before and 2 hours following
each of the next 3 doses of gabapentin. Pain scores, sedation scores, side effects and
morphine equivalents will be documented for one day following surgery.