Placebo Versus Antibiotics in Acute Exacerbations of Chronic Obstructive Pulmonary Disease (COPD)
Status:
Completed
Trial end date:
2008-08-01
Target enrollment:
Participant gender:
Summary
The role of antibiotic therapy in patients with COPD remains controversial. While the outcome
of several clinical trials is in favour of antibiotics, the quality of these studies in
insufficient. In this study the efficacy of doxycycline is compared to placebo. All
concommitant treatment (steroids, bronchodilator therapy, physiotherapy) is standardized.
The investigators hypothesize that patients with an acute exacerbations will have a better
outcome when treated with antibiotics.