Placebo Effects in the Treatment of Depression: Cognitive and Neural Mechanisms
Status:
Completed
Trial end date:
2016-06-01
Target enrollment:
Participant gender:
Summary
Studies of the neural mechanisms underlying placebo effects in antidepressant clinical trials
largely have been limited to demonstrating objective differences in brain activity between
responders and non-responders to placebo. This 8 week Placebo-controlled and Open groups
study employs a novel antidepressant trial design with integrated functional magnetic
resonance imaging (fMRI) to manipulate patient expectancy and examine its neural mediators.