Overview

Placebo-Controlled Study of Brazikumab in Participants With Moderately to Severely Active Ulcerative Colitis

Status:
Recruiting
Trial end date:
2024-04-22
Target enrollment:
0
Participant gender:
All
Summary
The present study (D5272C00001/Legacy #3151-201-008) aims to evaluate the efficacy and safety of brazikumab in patients with moderately to severely active UC and will include assessments of clinical responses as demonstrated by improvement of symptoms and of colonic mucosal appearance as observed on endoscopy.
Phase:
Phase 2
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
AstraZeneca
Treatments:
Vedolizumab
Criteria
Inclusion Criteria:

1. Ability to provide informed consent

2. Aged 18 to 80 years of age

3. Diagnosis of UC with an onset of symptoms for a minimum of 3 months prior to Screening

4. Evidence of UC extending proximal to the rectum (≥ 15 cm of involved colon)

5. Moderately to severely active UC as defined by:

1. Average daily mMS Stool Frequency subscore ≥ 1 AND Average daily mMS Rectal
Bleeding subscore ≥ 1

2. Modified Mayo endoscopic subscore of ≥ 2 based on a full colonoscopy within 14
days prior to randomization.

6. Participant had an inadequate response or intolerance to intervention with
conventional treatment or prior biological treatment or demonstrated CS dependence for
the treatment of UC. For participants who have previously used biological treatment, a
participant may have failed up to 3 biologics that include up to 2 different
mechanisms of action.

7. Participants taking 5-aminosalicylates, oral prednisone (or equivalent), oral
budesonide, or immunomodulators must be at a stable dose or discontinued. Topical
(rectal) aminosalicylic acid or topical (rectal) steroids should be discontinued.

8. Female participants of childbearing potential must have a negative urine pregnancy
test prior to administration of study intervention and must agree to use a highly
effective method of birth control throughout the study

9. Women not of childbearing potential are defined as women who are either permanently
sterilized (hysterectomy, bilateral oophorectomy, or bilateral salpingectomy), or who
are postmenopausal.

10. Non sterilized males who are sexually active with a female partner of childbearing
potential should use condoms during treatment and until the end of relevant systemic
exposure in the male participant, plus a further 18 weeks.

11. No known history of active TB or latent TB without completion of appropriate
intervention.

Complete inclusion criteria are in the Clinical Study Protocol

Exclusion Criteria:

1. Participant has UC limited to the rectum (ie, not beyond 15 cm of the anal verge).

2. Current diagnosis of fulminant colitis, a diagnosis of CD or indeterminate colitis,
presence or history of a fistula consistent with CD, primary sclerosing cholangitis,
celiac disease, or untreated bile acid malabsorption. Participants with a history of
toxic megacolon within 12 months of screening are excluded.

3. History of subtotal colectomy with ileorectostomy or colectomy with ileoanal pouch,
Koch pouch, ileostomy, or other prior colonic resection, or need for surgical
intervention for control of UC anticipated within 6 months.

4. Participant has received the following treatment:

1. Infliximab: within 8 weeks prior to randomization.

2. Adalimumab, certolizumab pegol, or golimumab: within 8 weeks prior to
randomization.

3. Vedolizumab or ustekinumab within 12 weeks of randomization.

4. Other prohibited medication, biologic or small molecule treatment within 5
half-lives prior to randomization.

5. Fecal microbiota transplantation: within 8 weeks prior to randomization.

5. Except for ustekinumab, prior exposure to any biologic agent targeting IL-12 or IL-23.

6. Known history of allergy to the study intervention formulation or any of its
excipients or components of the delivery device, or to any other biologic therapy.

7. Participant received cyclosporine, mycophenolate mofetil, sirolimus (rapamycin),
thalidomide, tacrolimus (FK-506), or tofacitinib within 2 weeks prior to Screening.

8. Participants who received IV or intramuscular steroids within 2 weeks prior to
Screening.

9. Participant is currently enrolled in another investigational device or drug study, or
is within 35 days or 5 half-lives, whichever is longer, since ending another
investigational device or drug study(s), or receiving other investigational agent(s).

10. Participant received a transfusion of blood, plasma, or platelets within 30 days prior
to Screening.

11. Participant received a Bacille Calmette-Guérin vaccination within 12 months of
randomization or any other live vaccine less than 4 weeks prior to randomization.

12. Participant has any of the following criteria related to infections:

1. Evidence of a recent systemic fungal infection, requiring inpatient
hospitalization, and/or antifungal treatment.

2. Any infection requiring hospitalization or treatment with IV anti-infectives
within 4 weeks of Screening.

3. Cytomegalovirus or Epstein-Barr virus infection that has not resolved within 8
weeks prior to Screening.

4. Clinically significant chronic infection that has not resolved within 8 weeks of
Screening.

5. Nonserious infection requiring oral anti-infectives within 2 weeks prior to
randomization must be further discussed with study medical monitor.

6. Clinical evidence of or suspected to have an abscess during Screening.

7. Any underlying condition that predisposes the participant to infections.

8. Participant had previous allogenic bone marrow transplant or history of organ or
cell-based transplantation.

9. Clinically significant active infection or signs/symptoms of infection that has
the potential to worsen with immunosuppressive therapy.

10. Signs or symptoms of ongoing infection due to intestinal pathogens.

13. Participant has known or suspected history of chronic use of NSAIDs and/or opiates,
drug, or alcohol abuse.

14. History of cancer with the following exceptions: history of basal cell carcinoma
and/or squamous cell carcinoma of the skin OR carcinoma in situ of the cervix; with
apparent successful curative therapy, greater than 12 months prior to Screening.

15. Clinically significant cardiovascular conditions.

16. Prolonged QTcF interval or conditions leading to additional risk for QT prolongation.

17. Clinically significant kidney disease

18. Abnormal laboratory results at Screening as defined in the study protocol

19. Participant is pregnant or breastfeeding or plans to become pregnant during the study.

20. Participant has other known, pre-existing, clinically significant medical conditions
that are not associated with UC and are uncontrolled with standard treatment.

21. Participant has any disorder that may compromise the ability of the participant to
give written informed consent and/or to comply with all required study procedures.

22. Employees of the clinical study site or any other individuals involved with the
conduct of the study, or immediate family members of such individuals.

Complete exclusion criteria are in the Clinical Study Protocol