Overview

Placebo Controlled Double Blind Crossover Trial of Metformin for Brain Repair in Children With Cranial-Spinal Radiation for Medulloblastoma

Status:
Completed

Trial end date:
2017-12-01

Target enrollment:

Participant gender:

Summary

A placebo controlled double blind crossover trial of metformin in 30 children treated with radiation for medulloblastoma - the most common malignant brain tumour. The investigators will use tests of thinking and learning and brain imaging techniques to examine whether metformin can enhance cognition or promote brain repair following radiation-induced brain injury.

Phase:

Phase 3

Details

Lead Sponsor:

The Hospital for Sick Children

Treatments:

Metformin