Overview Pioglitazone for Oral Premalignant Lesions Status: Terminated Trial end date: 2014-03-01 Target enrollment: Participant gender: Summary The goal of this clinical research study is to learn how Actos (pioglitazone) may affect oral premalignant lesions (OPLs) and/or the risk of mouth cancer. The safety of this drug will also be studied. Phase: Phase 2 Details Lead Sponsor: National Cancer Institute (NCI)Treatments: Pioglitazone