HYPOTHESIS: Treatment with pioglitazone is more effective in reducing resistin concentrations
and insulin resistance than metformin in children with Type 2 Diabetes (T2D).
MATERIAL AND METHODS: Pediatric patients aged 8-17 with T2D as defined by the American
Diabetes Association (ADA) were included, not under treatment or who had been treated
exclusively with diet and exercise or who only received an anti-diabetic agent, as well as
those with a history of insulin use who had not applied insulin within 1 month before the
initial visit. History of T2D, hypertension, exercise, diet, age, gender and somatometry are
recorded. A Blood sample is taken to determine HbA1c, glucose, insulin and resistin.
STATISTICAL ANALYSIS: The percentual change over 4 weeks is analyzed for concentrations of
resistin, insulin resistance. Changes are noted for weeks 12, 24, 36 and 48 for resistin
concentrations, HbA1c and HOMA values. Baseline and final values are compared with a paired t
test. Lineal or logarithmic regression analysis is used to evaluate the relationship between
homeostasis model assessment of insulin resistance (HOMA-IR) and resistin concentrations. The
statistical significance between variables is determined using ANOVA. The effect of
confounding variables is analyzed with a test of co-variance analysis. Statistical
significance is considered as p <0.05.