Pioglitazone Therapy in Obese Children With Insulin Resistance: A Randomized, Controlled Pilot Study
Status:
Withdrawn
Trial end date:
2011-02-01
Target enrollment:
Participant gender:
Summary
The primary objective of this study is to examine the effects of four months of pioglitazone
vs. metformin treatment on HDL cholesterol, triglycerides, blood pressure, insulin
resistance, endothelial function, arterial stiffness, adipokines, oxidative stress, and blood
biomarkers of endothelial activation in obese insulin resistant children. 30 obese children
with elevated fasting insulin levels will be randomly assigned to pioglitazone or metformin
for 16 weeks. Change in clinical variables over the 16-week study period will be compared
between groups.
Phase:
Phase 4
Details
Lead Sponsor:
University of Minnesota University of Minnesota - Clinical and Translational Science Institute