Pimonidazole Hydrochloride to Detect Low Oxygen in Tuberculosis-Infected Lungs
Status:
Withdrawn
Trial end date:
2010-02-02
Target enrollment:
Participant gender:
Summary
This study will determine whether a drug called pimonidazole hydrochloride shows areas of low
oxygen in tuberculosis (TB)-infected lungs. Pimonidazole is a "low oxygen marker," an agent
designed to find areas in the body that are not getting enough oxygen. If it is found that TB
grows where oxygen is low, these results may help doctors decide what medicines would be most
effective for treating TB.
Patients 20 years of age or older who are scheduled for lung surgery at the National Masan
Tuberculosis Hospital in Masan, Korea to treat their TB may be eligible for this study.
Participants undergo the following procedures:
- Blood draw before surgery to test for hepatitis B and hepatitis C viruses.
- Pregnancy test for women who can become pregnant.
- Infusion of pimonidazole through a vein in the arm 24 hours before surgery. A part of
the patient's lung is removed during surgery. This tissue is examined under a microscope
for evidence of pimonidazole, which would indicate low oxygen.
- Blood sample collection during surgery and on the 7th and 14th days after surgery to
check liver function.
Phase:
Phase 2
Details
Lead Sponsor:
National Institute of Allergy and Infectious Diseases (NIAID)