PLUM evaluates the drug letrozole as a treatment for uterine fibroids. This study is a
randomized, blinded, placebo-controlled trial of oral letrozole among premenopausal women
with symptomatic uterine fibroids. Participants will be randomly assigned in a 1:1 ratio to
either oral letrozole 2.5mg/day for 6 months (Group A) or intermittent dosing with letrozole
2.5mg/day and an identical placebo capsule (Group B).