Pilot Study to Evaluate the Effect of Aromatase Inhibitor Therapy on Pain Threshold in Breast Cancer Patients
Status:
Completed
Trial end date:
2013-02-01
Target enrollment:
Participant gender:
Summary
Postmenopausal women who have hormone receptor positive breast cancer are typically treated
with aromatase inhibitor medications, which substantially decrease the amount of estrogen
produced by their bodies. These medications are fairly well tolerated, but can cause aches
and pains which can be quite severe in some cases.
People experience pain differently. Estrogen appears to play a role in how we experience
pain. Therefore, decreasing estrogen levels may lead to more pain in some women than others.
The goal of this study is to evaluate perception of pain in women with breast cancer, and to
determine if differences in pain perception lead to more aches and pains in some women
treated with aromatase inhibitors.
In this study, we plan to enroll 55 women with breast cancer who are starting treatment with
an aromatase inhibitor. Participants will undergo testing to evaluate their perception of
pain, and will also complete a set of questionnaires. Testing will be conducted before
starting aromatase inhibitor therapy, as well as after 3 and 6 months of therapy. We will
investigate whether pre-existing differences in pain perception lead to different amounts of
pain during aromatase inhibitor therapy.