Pilot Study on Pairing Sedation Strategies and Weaning

• Status: Completed
• Trial end date: 2018-04-01
• Target enrollment: 0
• Participant gender: All

Summary

A three-arm, randomized, pilot feasibility, study to assess the effect three validated sedation strategies on outcomes of patient on mechanical ventilation.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: MemorialCare Health System
• Collaborator: Memorial Medical Center Foundation
• Treatments: Fentanyl; Midazolam; Propofol

Criteria

Inclusion Criteria:

1. ≥ 18 years of age

2. Mechanically ventilated with an expected duration of MV ≥ 48 hours

3. ICU team has initiated continuous sedative and/or /analgesic infusions

Exclusion criteria:

1. Admission after resuscitation from cardiac arrest

2. Admission with traumatic brain injury or another acute neurologic event (e,g. stroke, uncontrolled seizures).

3. History of severe dementia

4. Admission because of acute alcohol withdrawal or acute drug intoxication

5. Administration of more than 24 hours of continuous sedation

6. Allergy to fentanyl, midazolam, and/or propofol

7. Lack of informed consent