Pilot Study of Vardenafil and Carboplatin in Patients With Gliomas and Brain Metastases
Status:
Terminated
Trial end date:
2016-02-11
Target enrollment:
Participant gender:
Summary
This is a randomized pilot study to investigate the ability of a phosphodiesterase-V
inhibitor (vardenafil) to increase the concentration of systemically delivered chemotherapy,
carboplatin, in patients with recurrent malignant gliomas or metastatic brain cancer. This
study will also determine the toxicity and tolerability of a phosphodiesterase-V inhibitor
(vardenafil) in combination with intravenous carboplatin for patients with recurrent
malignant gliomas or metastatic brain cancer.