Pilot Study of Sodium Nitrite in Resuscitated Cardiac Arrest Patients
Status:
Completed
Trial end date:
2016-04-01
Target enrollment:
Participant gender:
Summary
Despite advances in cardiac arrest resuscitation survival from cardiac arrest is less than
20-30% and new therapies are urgently needed. Sodium nitrite infused during resuscitation
from cardiac arrest has recently been shown to improve survival in a mouse model of cardiac
arrest and our group is eager to test this hypothesis in a clinical trial. Our overall
hypothesis is that an infusion of 2 μmole/kg sodium nitrite during resuscitation will
increase the proportion of patients who will survive cardiac arrest. In preparation for a
clinical trial, preliminary safety and efficacy data (phase 1) is needed which is the primary
goal of this study.