Pilot Study of Pioglitazone for the Treatment of Moderate to Severe Asthma in Obese Asthmatics
Status:
Completed
Trial end date:
2012-04-01
Target enrollment:
Participant gender:
Summary
Asthmatics who are significantly overweight tend to have more severe symptoms, more flare
ups, and are more likely to have poorly-controlled asthma when compared to other asthmatics.
Researchers believe this occurs because excess adipose tissue (fat) in the body can cause
higher-than-normal levels of leptin and lower-than-normal levels of adiponectin in the blood.
The researchers of this study are testing a medication called pioglitazone in overweight
asthmatics because they believe it can help regulate leptin and adiponectin and that this may
improve symptoms of asthma.